| 2022-08-26 13:00:54August 26, 2022 | Lebanon vs Palmyra | 13:00:541:00 pm | N/A |
| 2022-08-26 17:30:17August 26, 2022 | Steel-High vs Bishop Canevin | 21 - 14 | N/A |
| 2022-08-26 19:00:02August 26, 2022 | Line Mountain vs Penns Valley Area | 13 - 41 | N/A |
| 2022-08-26 19:00:03August 26, 2022 | Reading vs CD East | 12 - 31 | N/A |
| 2022-08-26 19:00:07August 26, 2022 | Pine Grove vs Northern Lebanon | 14 - 9 | N/A |
| 2022-08-26 19:00:08August 26, 2022 | Newport vs Camp Hill | 7 - 43 | N/A |
| 2022-08-26 19:00:12August 26, 2022 | Susquehanna Twp. vs Milton Hershey | 16 - 26 | N/A |
| 2022-08-26 19:00:12August 26, 2022 | Red Land vs Northern York | 6 - 45 | N/A |
| 2022-08-26 19:00:13August 26, 2022 | Cedar Cliff vs Shippensburg | 10 - 28 | N/A |
| 2022-08-26 19:00:14August 26, 2022 | Manheim Township vs Cumberland Valley | 27 - 31 | N/A |
| 2022-08-26 19:00:23August 26, 2022 | Hamburg vs Halifax | 48 - 6 | N/A |
| 2022-08-26 19:00:23August 26, 2022 | West Perry vs Susquenita | 35 - 6 | N/A |
| 2022-08-26 19:00:23August 26, 2022 | Tri-Valley vs Minersville | 20 - 13 | N/A |
| 2022-08-26 19:00:26August 26, 2022 | Williams Valley vs Upper Dauphin | 34 - 22 | N/A |
| 2022-08-26 19:00:30August 26, 2022 | Greencastle-Antrim vs Big Spring | 28 - 13 | N/A |
| 2022-08-26 19:00:31August 26, 2022 | Hershey vs Gettysburg | 14 - 25 | N/A |
| 2022-08-26 19:00:33August 26, 2022 | Trinity vs Delone Catholic | 35 - 7 | N/A |
| 2022-08-26 19:00:33August 26, 2022 | Central Dauphin vs Central York | 36 - 19 | N/A |
| 2022-08-26 19:00:35August 26, 2022 | Clearfield vs Juniata | 7 - 20 | N/A |
| 2022-08-26 19:00:36August 26, 2022 | Boiling Springs vs Littlestown | 66 - 18 | N/A |
| 2022-08-26 19:00:37August 26, 2022 | Mifflin County vs Central Mountain | 14 - 7 | N/A |
| 2022-08-26 19:00:42August 26, 2022 | York County Tech vs James Buchanan | 20 - 22 | N/A |
| 2022-08-26 19:00:47August 26, 2022 | Lebanon vs Palmyra | 6 - 14 | N/A |
| 2022-08-26 19:00:48August 26, 2022 | Mechanicsburg vs Carlisle | 14 - 28 | N/A |
| 2022-08-26 19:00:53August 26, 2022 | Holidaysburg vs Altoona | 9 - 19 | N/A |
| 2022-08-26 19:00:55August 26, 2022 | Williamsport vs State College | 14 - 42 | N/A |
| 2022-08-26 19:00:58August 26, 2022 | Waynesboro vs Spring Grove | 14 - 46 | N/A |
| 2022-08-26 20:00:32August 26, 2022 | Pallotti vs Harrisburg (at Chambersburg) | 20:00:328:00 pm | N/A |
| 2022-08-27 17:30:55August 27, 2022 | Imhotep Charter vs Bishop McDevitt (at Chambersburg) | 17:30:555:30 pm | N/A |
| 2022-08-27 19:00:17August 27, 2022 | East Pennsboro vs York Suburban | 19:00:177:00 pm | N/A |
| 2022-08-27 20:30:39August 27, 2022 | Central Bucks East vs Chambersburg | 38 - 21 | N/A |
