| 2022-09-22 19:00:30September 22, 2022 | Greencastle-Antrim vs East Pennsboro | 13 - 30 | N/A |
| 2022-09-22 19:00:48September 22, 2022 | Susquehanna Twp. vs Shippensburg | 13 - 29 | N/A |
| 2022-09-22 19:00:58September 22, 2022 | Gettysburg vs Mechanicsburg | 14 - 0 | N/A |
| 2022-09-23 19:00:03September 23, 2022 | Cedar Cliff vs Bishop McDevitt | 7 - 48 | N/A |
| 2022-09-23 19:00:11September 23, 2022 | Palmyra vs Mifflin County | 0 - 14 | N/A |
| 2022-09-23 19:00:13September 23, 2022 | Carlisle vs Chambersburg | 18 - 7 | N/A |
| 2022-09-23 19:00:14September 23, 2022 | Big Spring vs Steel-High | 7 - 41 | N/A |
| 2022-09-23 19:00:28September 23, 2022 | Boiling Springs vs Trinity | 14 - 26 | N/A |
| 2022-09-23 19:00:29September 23, 2022 | James Buchanan vs West Perry | 8 - 51 | N/A |
| 2022-09-23 19:00:33September 23, 2022 | Susquenita vs Line Mountain | 35 - 21 | N/A |
| 2022-09-23 19:00:46September 23, 2022 | Juniata vs Halifax | 55 - 0 | N/A |
| 2022-09-23 19:00:47September 23, 2022 | Upper Dauphin vs Newport | 41 - 20 | N/A |
| 2022-09-23 19:00:48September 23, 2022 | Lower Dauphin vs Red Land | 49 - 3 | N/A |
| 2022-09-23 19:00:50September 23, 2022 | Altoona vs CD East | 28 - 14 | N/A |
| 2022-09-23 19:00:55September 23, 2022 | Milton Hershey vs Hershey | 21 - 28 | N/A |
| 2022-09-23 19:00:58September 23, 2022 | Central Dauphin vs State College | 8 - 19 | N/A |
| 2022-09-24 13:00:54September 24, 2022 | Cumberland Valley vs Harrisburg | 13:00:541:00 pm | N/A |
| 2022-09-24 19:00:50September 24, 2022 | Northern York vs Waynesboro | 19:00:507:00 pm | N/A |
