| 2022-10-14 19:00:04October 14, 2022 | Carlisle vs Cumberland Valley | 19:00:047:00 pm | N/A |
| 2022-10-14 19:00:13October 14, 2022 | Chambersburg vs CD East | 19:00:137:00 pm | N/A |
| 2022-10-14 19:00:13October 14, 2022 | Mifflin County vs Hershey | 19:00:137:00 pm | N/A |
| 2022-10-14 19:00:16October 14, 2022 | Lower Dauphin vs Milton Hershey | 19:00:167:00 pm | N/A |
| 2022-10-14 19:00:17October 14, 2022 | Greencastle-Antrim vs Gettysburg | 19:00:177:00 pm | N/A |
| 2022-10-14 19:00:20October 14, 2022 | Central Dauphin vs Altoona | 19:00:207:00 pm | N/A |
| 2022-10-14 19:00:21October 14, 2022 | Palmyra vs Cedar Cliff | 19:00:217:00 pm | N/A |
| 2022-10-14 19:00:22October 14, 2022 | East Pennsboro vs Shippensburg | 19:00:227:00 pm | N/A |
| 2022-10-14 19:00:22October 14, 2022 | Juniata vs Upper Dauphin | 19:00:227:00 pm | N/A |
| 2022-10-14 19:00:24October 14, 2022 | James Buchanan vs Line Mountain | 19:00:247:00 pm | N/A |
| 2022-10-14 19:00:25October 14, 2022 | Northern York vs Susquehanna Twp. | 19:00:257:00 pm | N/A |
| 2022-10-14 19:00:27October 14, 2022 | Waynesboro vs Mechanicsburg | 19:00:277:00 pm | N/A |
| 2022-10-14 19:00:33October 14, 2022 | Trinity vs Camp Hill | 19:00:337:00 pm | N/A |
| 2022-10-14 19:00:34October 14, 2022 | Halifax vs Susquenita | 19:00:347:00 pm | N/A |
| 2022-10-14 19:00:40October 14, 2022 | Steel-High vs Newport | 19:00:407:00 pm | N/A |
| 2022-10-14 19:00:48October 14, 2022 | Red Land vs Bishop McDevitt | 19:00:487:00 pm | N/A |
| 2022-10-14 19:00:48October 14, 2022 | Boiling Springs vs Big Spring | 19:00:487:00 pm | N/A |
| 2022-10-15 13:00:40October 15, 2022 | State College vs Harrisburg | 13:00:401:00 pm | N/A |
