| 2022-10-14 19:00:04October 14, 2022 | Carlisle vs Cumberland Valley | 26 - 20 | N/A |
| 2022-10-14 19:00:13October 14, 2022 | Chambersburg vs CD East | 7 - 3 | N/A |
| 2022-10-14 19:00:13October 14, 2022 | Mifflin County vs Hershey | 24 - 20 | N/A |
| 2022-10-14 19:00:17October 14, 2022 | Greencastle-Antrim vs Gettysburg | 28 - 42 | N/A |
| 2022-10-14 19:00:20October 14, 2022 | Central Dauphin vs Altoona | 34 - 14 | N/A |
| 2022-10-14 19:00:21October 14, 2022 | Palmyra vs Cedar Cliff | 6 - 38 | N/A |
| 2022-10-14 19:00:22October 14, 2022 | East Pennsboro vs Shippensburg | 14 - 34 | N/A |
| 2022-10-14 19:00:22October 14, 2022 | Juniata vs Upper Dauphin | 13 - 20 | N/A |
| 2022-10-14 19:00:24October 14, 2022 | James Buchanan vs Line Mountain | 8 - 48 | N/A |
| 2022-10-14 19:00:25October 14, 2022 | Northern York vs Susquehanna Twp. | 37 - 38 | N/A |
| 2022-10-14 19:00:27October 14, 2022 | Waynesboro vs Mechanicsburg | 0 - 28 | N/A |
| 2022-10-14 19:00:33October 14, 2022 | Trinity vs Camp Hill | 26 - 0 | N/A |
| 2022-10-14 19:00:34October 14, 2022 | Halifax vs Susquenita | 0 - 35 | N/A |
| 2022-10-14 19:00:40October 14, 2022 | Steel-High vs Newport | 68 - 14 | N/A |
| 2022-10-14 19:00:48October 14, 2022 | Red Land vs Bishop McDevitt | 19:00:487:00 pm | N/A |
| 2022-10-14 19:00:48October 14, 2022 | Boiling Springs vs Big Spring | 27 - 33 | N/A |
| 2022-10-15 13:00:40October 15, 2022 | State College vs Harrisburg | 20 - 6 | N/A |
| 2022-10-16 13:30:51October 16, 2022 | Lower Dauphin vs Milton Hershey | 13:30:511:30 pm | N/A |
