| 2022-09-09 19:00:00September 9, 2022 | Gettysburg vs Boiling Springs | 35 - 20 | N/A |
| 2022-09-09 19:00:00September 9, 2022 | Big Spring vs Newport | 47 - 0 | N/A |
| 2022-09-09 19:00:04September 9, 2022 | Central Dauphin vs Coatesville | 28 - 34 | N/A |
| 2022-09-09 19:00:04September 9, 2022 | Cumberland Valley vs Spring Ford | 28 - 16 | N/A |
| 2022-09-09 19:00:08September 9, 2022 | Donegal vs Palmyra | 30 - 13 | N/A |
| 2022-09-09 19:00:08September 9, 2022 | Milton Hershey vs East Pennsboro | 8 - 17 | N/A |
| 2022-09-09 19:00:09September 9, 2022 | Bishop McDevitt vs La Salle College | 56 - 7 | N/A |
| 2022-09-09 19:00:09September 9, 2022 | Northern York vs Dover | 28 - 29 | N/A |
| 2022-09-09 19:00:12September 9, 2022 | Carlisle vs York | 47 - 54 | N/A |
| 2022-09-09 19:00:12September 9, 2022 | Shippensburg vs Spring Grove | 21 - 14 | N/A |
| 2022-09-09 19:00:17September 9, 2022 | Hershey vs Dallastown | 30 - 44 | N/A |
| 2022-09-09 19:00:21September 9, 2022 | Mifflin County vs Altoona | 0 - 38 | N/A |
| 2022-09-09 19:00:27September 9, 2022 | Schuylkill Valley vs Susquenita | 31 - 13 | N/A |
| 2022-09-09 19:00:28September 9, 2022 | Chambersburg vs Waynesboro | 17 - 0 | N/A |
| 2022-09-09 19:00:32September 9, 2022 | Holidaysburg vs State College | 3 - 45 | N/A |
| 2022-09-09 19:00:38September 9, 2022 | Hancock vs Halifax | 0 - 53 | N/A |
| 2022-09-09 19:00:39September 9, 2022 | Biglerville vs James Buchanan | 21 - 14 | N/A |
| 2022-09-09 19:00:47September 9, 2022 | Line Mountain vs Tri-Valley | 28 - 35 | N/A |
| 2022-09-09 19:00:48September 9, 2022 | Camp Hill vs Upper Dauphin | 26 - 12 | N/A |
| 2022-09-09 19:00:50September 9, 2022 | Northeastern vs CD East | 7 - 34 | N/A |
| 2022-09-09 19:00:53September 9, 2022 | Mechanicsburg vs Red Land | 15 - 16 | N/A |
| 2022-09-09 19:00:53September 9, 2022 | Elizabethtown vs Lower Dauphin | 41 - 28 | N/A |
| 2022-09-09 19:00:56September 9, 2022 | Delone Catholic vs Greencastle-Antrim | 0 - 35 | N/A |
| 2022-09-09 19:00:57September 9, 2022 | Cedar Cliff vs J.P. McCaskey | 44 - 0 | N/A |
| 2022-09-09 19:00:57September 9, 2022 | West Perry vs Juniata | 24 - 0 | N/A |
| 2022-09-09 19:00:59September 9, 2022 | Shippensburg vs Northern York | 19:00:597:00 pm | N/A |
| 2022-09-10 13:00:55September 10, 2022 | Manheim Township vs Harrisburg | 13:00:551:00 pm | N/A |
| 2022-09-10 13:30:28September 10, 2022 | Trinity vs Wyomissing | 13:30:281:30 pm | N/A |
