| 2022-09-15 19:00:20September 15, 2022 | Bishop McDevitt vs Palmyra | 49 - 3 | N/A |
| 2022-09-15 19:00:41September 15, 2022 | Mifflin County vs Lower Dauphin | 28 - 7 | N/A |
| 2022-09-16 19:00:01September 16, 2022 | Red Land vs Milton Hershey | 10 - 35 | N/A |
| 2022-09-16 19:00:07September 16, 2022 | Chambersburg vs Central Dauphin | 35 - 42 | N/A |
| 2022-09-16 19:00:14September 16, 2022 | Halifax vs James Buchanan | 7 - 27 | N/A |
| 2022-09-16 19:00:16September 16, 2022 | Shippensburg vs Northern York | 19:00:167:00 pm | N/A |
| 2022-09-16 19:00:31September 16, 2022 | CD East vs Cumberland Valley | 14 - 45 | N/A |
| 2022-09-16 19:00:36September 16, 2022 | Newport vs Juniata | 0 - 36 | N/A |
| 2022-09-16 19:00:38September 16, 2022 | Marian Catholic vs Line Mountain | 19 - 26 | N/A |
| 2022-09-16 19:00:41September 16, 2022 | Trinity vs West Perry | 14 - 40 | N/A |
| 2022-09-16 19:00:43September 16, 2022 | East Pennsboro vs Gettysburg | 11 - 27 | N/A |
| 2022-09-16 19:00:44September 16, 2022 | Steel-High vs Boiling Springs | 74 - 30 | N/A |
| 2022-09-16 19:00:46September 16, 2022 | Camp Hill vs Big Spring | 6 - 16 | N/A |
| 2022-09-16 19:00:47September 16, 2022 | State College vs Altoona | 55 - 14 | N/A |
| 2022-09-16 19:00:48September 16, 2022 | Waynesboro vs Greencastle-Antrim | 14 - 21 | N/A |
| 2022-09-16 19:00:49September 16, 2022 | Hershey vs Cedar Cliff | 21 - 20 | N/A |
| 2022-09-16 19:00:50September 16, 2022 | Shippensburg vs Northern York | 6 - 17 | N/A |
| 2022-09-16 19:00:54September 16, 2022 | Harrisburg vs Carlisle | 44 - 15 | N/A |
| 2022-09-16 19:00:55September 16, 2022 | Mechanicsburg vs Susquehanna Twp. | 34 - 27 | N/A |
| 2022-09-16 19:00:56September 16, 2022 | Susquenita vs Upper Dauphin | 7 - 30 | N/A |
