| 2022-10-07 19:00:02October 7, 2022 | Hershey vs Bishop McDevitt | 0 - 70 | N/A |
| 2022-10-07 19:00:05October 7, 2022 | Altoona vs Chambersburg | 27 - 23 | N/A |
| 2022-10-07 19:00:19October 7, 2022 | Susquenita vs Newport | 52 - 14 | N/A |
| 2022-10-07 19:00:24October 7, 2022 | Palmyra vs Red Land | 9 - 19 | N/A |
| 2022-10-07 19:00:26October 7, 2022 | Mechanicsburg vs Shippensburg | 10 - 14 | N/A |
| 2022-10-07 19:00:33October 7, 2022 | Northern York vs East Pennsboro | 28 - 27 | N/A |
| 2022-10-07 19:00:36October 7, 2022 | Cedar Cliff vs Lower Dauphin | 24 - 21 | N/A |
| 2022-10-07 19:00:36October 7, 2022 | Gettysburg vs Waynesboro | 21 - 10 | N/A |
| 2022-10-07 19:00:36October 7, 2022 | Halifax vs Line Mountain | 13 - 43 | N/A |
| 2022-10-07 19:00:40October 7, 2022 | Carlisle vs State College | 20 - 49 | N/A |
| 2022-10-07 19:00:43October 7, 2022 | Big Spring vs West Perry | 14 - 31 | N/A |
| 2022-10-07 19:00:48October 7, 2022 | Susquehanna Twp. vs Greencastle-Antrim | 38 - 23 | N/A |
| 2022-10-07 19:00:51October 7, 2022 | Upper Dauphin vs James Buchanan | 19:00:517:00 pm | N/A |
| 2022-10-07 19:00:56October 7, 2022 | Juniata vs Boiling Springs | 13 - 7 | N/A |
| 2022-10-07 19:00:58October 7, 2022 | Cumberland Valley vs Central Dauphin | 35 - 21 | N/A |
| 2022-10-08 12:00:56October 8, 2022 | Camp Hill vs Steel-High | 12:00:5612:00 pm | N/A |
| 2022-10-08 13:00:14October 8, 2022 | CD East vs Harrisburg | 13:00:141:00 pm | N/A |
