| 2022-10-20 19:00:22October 20, 2022 | Camp Hill vs West Perry | 20 - 42 | N/A |
| 2022-10-21 19:00:03October 21, 2022 | Cedar Cliff vs Red Land | 42 - 0 | N/A |
| 2022-10-21 19:00:08October 21, 2022 | Shippensburg vs Waynesboro | 33 - 13 | N/A |
| 2022-10-21 19:00:09October 21, 2022 | Line Mountain vs Juniata | 10 - 14 | N/A |
| 2022-10-21 19:00:10October 21, 2022 | Milton Hershey vs Palmyra | 29 - 16 | N/A |
| 2022-10-21 19:00:12October 21, 2022 | Gettysburg vs Northern York | 23 - 24 | N/A |
| 2022-10-21 19:00:15October 21, 2022 | Harrisburg vs Chambersburg | 41 - 0 | N/A |
| 2022-10-21 19:00:18October 21, 2022 | Hershey vs Lower Dauphin | 31 - 21 | N/A |
| 2022-10-21 19:00:25October 21, 2022 | Susquehanna Twp. vs East Pennsboro | 19:00:257:00 pm | N/A |
| 2022-10-21 19:00:30October 21, 2022 | Steel-High vs Trinity | 35 - 28 | N/A |
| 2022-10-21 19:00:35October 21, 2022 | Bishop McDevitt vs Mifflin County | 54 - 6 | N/A |
| 2022-10-21 19:00:38October 21, 2022 | Upper Dauphin vs Big Spring | 42 - 35 | N/A |
| 2022-10-21 19:00:47October 21, 2022 | Cumberland Valley vs State College | 31 - 48 | N/A |
| 2022-10-21 19:00:47October 21, 2022 | Susquenita vs James Buchanan | 19:00:477:00 pm | N/A |
| 2022-10-21 19:00:50October 21, 2022 | Carrick vs Trinity | 19:00:507:00 pm | N/A |
| 2022-10-21 19:00:51October 21, 2022 | Altoona vs Carlisle | 14 - 24 | N/A |
| 2022-10-21 19:00:52October 21, 2022 | Newport vs Halifax | 14 - 7 | N/A |
| 2022-10-21 19:00:53October 21, 2022 | CD East vs Central Dauphin | 32 - 0 | N/A |
| 2022-10-21 19:00:53October 21, 2022 | Mechanicsburg vs Greencastle-Antrim | 20 - 14 | N/A |
