| 2022-10-20 19:00:22October 20, 2022 | Camp Hill vs West Perry | 19:00:227:00 pm | N/A |
| 2022-10-21 19:00:03October 21, 2022 | Cedar Cliff vs Red Land | 19:00:037:00 pm | N/A |
| 2022-10-21 19:00:08October 21, 2022 | Shippensburg vs Waynesboro | 19:00:087:00 pm | N/A |
| 2022-10-21 19:00:09October 21, 2022 | Line Mountain vs Juniata | 19:00:097:00 pm | N/A |
| 2022-10-21 19:00:10October 21, 2022 | Milton Hershey vs Palmyra | 19:00:107:00 pm | N/A |
| 2022-10-21 19:00:12October 21, 2022 | Gettysburg vs Northern York | 19:00:127:00 pm | N/A |
| 2022-10-21 19:00:15October 21, 2022 | Harrisburg vs Chambersburg | 19:00:157:00 pm | N/A |
| 2022-10-21 19:00:18October 21, 2022 | Hershey vs Lower Dauphin | 19:00:187:00 pm | N/A |
| 2022-10-21 19:00:25October 21, 2022 | Susquehanna Twp. vs East Pennsboro | 19:00:257:00 pm | N/A |
| 2022-10-21 19:00:30October 21, 2022 | Steel-High vs Trinity | 19:00:307:00 pm | N/A |
| 2022-10-21 19:00:35October 21, 2022 | Bishop McDevitt vs Mifflin County | 19:00:357:00 pm | N/A |
| 2022-10-21 19:00:38October 21, 2022 | Upper Dauphin vs Big Spring | 19:00:387:00 pm | N/A |
| 2022-10-21 19:00:47October 21, 2022 | Cumberland Valley vs State College | 19:00:477:00 pm | N/A |
| 2022-10-21 19:00:47October 21, 2022 | Susquenita vs James Buchanan | 19:00:477:00 pm | N/A |
| 2022-10-21 19:00:50October 21, 2022 | Carrick vs Trinity | 19:00:507:00 pm | N/A |
| 2022-10-21 19:00:51October 21, 2022 | Altoona vs Carlisle | 19:00:517:00 pm | N/A |
| 2022-10-21 19:00:52October 21, 2022 | Newport vs Halifax | 19:00:527:00 pm | N/A |
| 2022-10-21 19:00:53October 21, 2022 | CD East vs Central Dauphin | 19:00:537:00 pm | N/A |
| 2022-10-21 19:00:53October 21, 2022 | Mechanicsburg vs Greencastle-Antrim | 19:00:537:00 pm | N/A |
