| 2022-10-28 19:00:05October 28, 2022 | Milton Hershey vs Cedar Cliff | 14 - 38 | N/A |
| 2022-10-28 19:00:06October 28, 2022 | Northern York vs Mechanicsburg | 21 - 14 | N/A |
| 2022-10-28 19:00:19October 28, 2022 | Carlisle vs CD East | 27 - 14 | N/A |
| 2022-10-28 19:00:19October 28, 2022 | State College vs Chambersburg | 36 - 7 | N/A |
| 2022-10-28 19:00:20October 28, 2022 | East Pennsboro vs Waynesboro | 10 - 13 | N/A |
| 2022-10-28 19:00:31October 28, 2022 | Lower Dauphin vs Bishop McDevitt | 14 - 68 | N/A |
| 2022-10-28 19:00:31October 28, 2022 | Red Land vs Mifflin County | 14 - 41 | N/A |
| 2022-10-28 19:00:36October 28, 2022 | Boiling Springs vs Camp Hill | 35 - 20 | N/A |
| 2022-10-28 19:00:36October 28, 2022 | Gettysburg vs Susquehanna Twp. | 23 - 16 | N/A |
| 2022-10-28 19:00:36October 28, 2022 | Upper Dauphin vs Line Mountain | 25 - 14 | N/A |
| 2022-10-28 19:00:36October 28, 2022 | James Buchanan vs Newport | 12 - 17 | N/A |
| 2022-10-28 19:00:43October 28, 2022 | Altoona vs Cumberland Valley | 6 - 37 | N/A |
| 2022-10-28 19:00:46October 28, 2022 | Trinity vs Halifax | 55 - 14 | N/A |
| 2022-10-28 19:00:52October 28, 2022 | Greencastle-Antrim vs Shippensburg | 42 - 26 | N/A |
| 2022-10-28 19:00:52October 28, 2022 | Juniata vs Susquenita | 19 - 3 | N/A |
| 2022-10-28 19:00:53October 28, 2022 | Palmyra vs Hershey | 7 - 17 | N/A |
| 2022-10-29 12:00:13October 29, 2022 | West Perry vs Steel-High | 12:00:1312:00 pm | N/A |
| 2022-10-29 13:00:51October 29, 2022 | Central Dauphin vs Harrisburg | 13:00:511:00 pm | N/A |
