| 2022-10-28 19:00:05October 28, 2022 | Milton Hershey vs Cedar Cliff | 19:00:057:00 pm | N/A |
| 2022-10-28 19:00:06October 28, 2022 | Northern York vs Mechanicsburg | 19:00:067:00 pm | N/A |
| 2022-10-28 19:00:13October 28, 2022 | West Perry vs Steel-High | 19:00:137:00 pm | N/A |
| 2022-10-28 19:00:19October 28, 2022 | Carlisle vs CD East | 19:00:197:00 pm | N/A |
| 2022-10-28 19:00:19October 28, 2022 | State College vs Chambersburg | 19:00:197:00 pm | N/A |
| 2022-10-28 19:00:20October 28, 2022 | East Pennsboro vs Waynesboro | 19:00:207:00 pm | N/A |
| 2022-10-28 19:00:31October 28, 2022 | Lower Dauphin vs Bishop McDevitt | 19:00:317:00 pm | N/A |
| 2022-10-28 19:00:31October 28, 2022 | Red Land vs Mifflin County | 19:00:317:00 pm | N/A |
| 2022-10-28 19:00:36October 28, 2022 | Boiling Springs vs Camp Hill | 19:00:367:00 pm | N/A |
| 2022-10-28 19:00:36October 28, 2022 | Gettysburg vs Susquehanna Twp. | 19:00:367:00 pm | N/A |
| 2022-10-28 19:00:36October 28, 2022 | Upper Dauphin vs Line Mountain | 19:00:367:00 pm | N/A |
| 2022-10-28 19:00:36October 28, 2022 | James Buchanan vs Newport | 19:00:367:00 pm | N/A |
| 2022-10-28 19:00:43October 28, 2022 | Altoona vs Cumberland Valley | 19:00:437:00 pm | N/A |
| 2022-10-28 19:00:46October 28, 2022 | Trinity vs Halifax | 19:00:467:00 pm | N/A |
| 2022-10-28 19:00:52October 28, 2022 | Greencastle-Antrim vs Shippensburg | 19:00:527:00 pm | N/A |
| 2022-10-28 19:00:52October 28, 2022 | Juniata vs Susquenita | 19:00:527:00 pm | N/A |
| 2022-10-28 19:00:53October 28, 2022 | Palmyra vs Hershey | 19:00:537:00 pm | N/A |
| 2022-10-29 13:00:51October 29, 2022 | Central Dauphin vs Harrisburg | 13:00:511:00 pm | N/A |
