| 2022-09-29 19:00:16September 29, 2022 | Chambersburg vs Cumberland Valley | 14 - 38 | N/A |
| 2022-09-29 19:00:30September 29, 2022 | Central Dauphin vs Carlisle | 42 - 14 | N/A |
| 2022-09-30 19:00:03September 30, 2022 | Bishop McDevitt vs Milton Hershey | 68 - 22 | N/A |
| 2022-09-30 19:00:11September 30, 2022 | West Perry vs Boiling Springs | 54 - 21 | N/A |
| 2022-09-30 19:00:25September 30, 2022 | Lower Dauphin vs Palmyra | 42 - 7 | N/A |
| 2022-09-30 19:00:27September 30, 2022 | State College vs CD East | 42 - 14 | N/A |
| 2022-09-30 19:00:34September 30, 2022 | James Buchanan vs Juniata | 0 - 48 | N/A |
| 2022-09-30 19:00:38September 30, 2022 | Shippensburg vs Gettysburg | 14 - 17 | N/A |
| 2022-09-30 19:00:39September 30, 2022 | Susquenita vs Camp Hill | 7 - 10 | N/A |
| 2022-09-30 19:00:40September 30, 2022 | Red Land vs Hershey | 7 - 27 | N/A |
| 2022-09-30 19:00:43September 30, 2022 | Greencastle-Antrim vs Northern York | 18 - 29 | N/A |
| 2022-09-30 19:00:44September 30, 2022 | Waynesboro vs Susquehanna Twp. | 0 - 23 | N/A |
| 2022-09-30 19:00:45September 30, 2022 | Mifflin County vs Cedar Cliff | 14 - 28 | N/A |
| 2022-09-30 19:00:48September 30, 2022 | Newport vs Line Mountain | 23 - 24 | N/A |
| 2022-09-30 19:00:53September 30, 2022 | Trinity vs Big Spring | 38 - 21 | N/A |
| 2022-09-30 19:00:54September 30, 2022 | East Pennsboro vs Mechanicsburg | 7 - 10 | N/A |
| 2022-09-30 19:00:55September 30, 2022 | Harrisburg vs Altoona | 48 - 0 | N/A |
