| 2022-09-29 19:00:16September 29, 2022 | Chambersburg vs Cumberland Valley | 19:00:167:00 pm | N/A |
| 2022-09-29 19:00:30September 29, 2022 | Central Dauphin vs Carlisle | 19:00:307:00 pm | N/A |
| 2022-09-30 19:00:03September 30, 2022 | Bishop McDevitt vs Milton Hershey | 19:00:037:00 pm | N/A |
| 2022-09-30 19:00:11September 30, 2022 | West Perry vs Boiling Springs | 19:00:117:00 pm | N/A |
| 2022-09-30 19:00:25September 30, 2022 | Lower Dauphin vs Palmyra | 19:00:257:00 pm | N/A |
| 2022-09-30 19:00:27September 30, 2022 | State College vs CD East | 19:00:277:00 pm | N/A |
| 2022-09-30 19:00:34September 30, 2022 | James Buchanan vs Juniata | 19:00:347:00 pm | N/A |
| 2022-09-30 19:00:38September 30, 2022 | Shippensburg vs Gettysburg | 19:00:387:00 pm | N/A |
| 2022-09-30 19:00:39September 30, 2022 | Susquenita vs Camp Hill | 19:00:397:00 pm | N/A |
| 2022-09-30 19:00:40September 30, 2022 | Red Land vs Hershey | 19:00:407:00 pm | N/A |
| 2022-09-30 19:00:43September 30, 2022 | Greencastle-Antrim vs Northern York | 19:00:437:00 pm | N/A |
| 2022-09-30 19:00:44September 30, 2022 | Waynesboro vs Susquehanna Twp. | 19:00:447:00 pm | N/A |
| 2022-09-30 19:00:45September 30, 2022 | Mifflin County vs Cedar Cliff | 19:00:457:00 pm | N/A |
| 2022-09-30 19:00:48September 30, 2022 | Newport vs Line Mountain | 19:00:487:00 pm | N/A |
| 2022-09-30 19:00:53September 30, 2022 | Trinity vs Big Spring | 19:00:537:00 pm | N/A |
| 2022-09-30 19:00:54September 30, 2022 | East Pennsboro vs Mechanicsburg | 19:00:547:00 pm | N/A |
| 2022-09-30 19:00:55September 30, 2022 | Harrisburg vs Altoona | 19:00:557:00 pm | N/A |
